Graybug Vision’s pipeline products cover major eye indications that might lead to blindness, including neovascular (wet) age-related macular degeneration (nAMD), glaucoma, and corneal graft rejection. The lead product, GB-102, contains a single small molecule compound that inhibits multiple pathogenic angiogenesis pathways known to be involved in the choroidal neovascularization, the cause of nAMD.

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In clinical studies of nAMD, blockage of the vascular endothelial growth factor (VEGF) and platelet derived growth factor-beta (PDGF) angiogenesis pathways together has been shown to be more effective than blockage of a single pathway.  GB-102 is designed to provide the benefits of current multi-product therapies as a single dose administration with as few injections as twice per year.   Graybug Vision is also evaluating a proprietary library of compounds that have both intraocular pressure (IOP) lowering and neuroprotection.  Once the lead compound has been selected, Graybug Vision intends to develop an every 6 month subconjunctival injection product using its proprietary ocular delivery technologies.  In addition, proof of concept in an animal model has been demonstrated with a Graybug Vision product designed to treat corneal graft rejection.